Seminar Genetik II und Nanobiologie

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  • Beteiligte Poster: nellen
  • Forum: Fachschaftsforum
  • Forenbeschreibung: Fachschaft 10 - Mathematik & Naturwissenschaften
  • aus dem Unterforum: Informationen von Hochschullehrern
  • Antworten: 1
  • Forum gestartet am: Mittwoch 17.01.2007
  • Sprache: deutsch
  • Link zum Originaltopic: Seminar Genetik II und Nanobiologie
  • Letzte Antwort: vor 14 Jahren, 10 Monaten, 24 Tagen, 9 Stunden, 21 Minuten
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    Re: Seminar Genetik II und Nanobiologie

    nellen - 31.05.2009, 15:47

    Seminar Genetik II und Nanobiologie
    Unten finden Sie die Themen und Literaturliste für die beiden Seminartermine.
    Bitte tragen Sie sich auf der Liste am Schwarzen Brett der Genetik ein.
    Absprache mit den Referenten ähnlicher Themen ist sinnvoll!
    Referate sollten eine Länge von ca. 15 Min. haben (max. 15 ppt Folien).
    Für die Diskussion sind mindestens 15 Min. vorgesehen.
    Jedes Thema kann, muss aber nicht an beiden Terminen belegt werden.
    wolfgang nellen

    Themen:
    Chromatin (Drosophila)
    DNA methylation (methyltransferases and their biochemical function)
    Dnmt1, Dnmt3
    Dnmt2
    „The 6th base“ (hydroxy-methyl cytosine)
    Histon modifications
    Chromatin remodelling
    miRNAs
    piRNA
    qiRNA
    „RNA activation“
    Argonauten
    RdRPs
    heterochromatin organization in S. cerevisiae
    imprinting in mammals
    polycomb
    RITS
    RNA directed DNA methylation
    RISC

    Literatur
    (auf der Liste am Schwarzen Brett gibt es eine Zuordnung der Nummern zu den Themen!)


    1. Eissenberg, J.C. and G. Reuter, Cellular mechanism for targeting heterochromatin formation in Drosophila. Int Rev Cell Mol Biol, 2009. 273: p. 1-47.
    2. Rudolph, T., et al., Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell, 2007. 26(1): p. 103-15.
    3. Jurkowski, T.P., et al., Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. Rna, 2008. 14( 8 ): p. 1663-70.
    4. Hawkins, P.G., et al., Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res, 2009. 37(9): p. 2984-95.
    5. Jeltsch, A., Reading and writing DNA methylation. Nat Struct Mol Biol, 2008. 15(10): p. 1003-4.
    6. Phalke, S., et al., Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet, 2009. 41(6): p. 696-702.
    7. Dong, A., et al., Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. Nucleic Acids Res, 2001. 29(2): p. 439-48.
    8. Katoh, M., et al., Developmentally regulated DNA methylation in Dictyostelium discoideum. Eukaryot Cell, 2006. 5(1): p. 18-25.
    9. Kuhlmann, M., et al., Silencing of retrotransposons in Dictyostelium by DNA methylation and RNAi. Nucleic Acids Res, 2005. 33(19): p. 6405-17.
    10. Goll, M.G., et al., Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. Science, 2006. 311(5759): p. 395-8.
    11. Lavi, T., et al., Sensing DNA methylation in the protozoan parasite Entamoeba histolytica. Mol Microbiol, 2006. 62(5): p. 1373-86.
    12. Rai, K., et al., Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish. Genes Dev, 2007. 21(3): p. 261-6.
    13. Kriaucionis, S. and N. Heintz, The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain. Science, 2009.
    14. Tahiliani, M., et al., Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science, 2009. 324(5929): p. 930-5.
    15. Smith, B.C. and J.M. Denu, Chemical mechanisms of histone lysine and arginine modifications. Biochim Biophys Acta, 2009. 1789(1): p. 45-57.
    16. Ikegami, K., et al., Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development. Int J Dev Biol, 2009. 53(2-3): p. 203-14.
    17. Kutter, C. and P. Svoboda, miRNA, siRNA, piRNA: Knowns of the unknown. RNA Biol, 2008. 5(4): p. 181-8.
    18. Bartel, D.P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004. 116(2): p. 281-97.
    19. Filipowicz, W., et al., Post-transcriptional gene silencing by siRNAs and miRNAs. Curr Opin Struct Biol, 2005. 15(3): p. 331-41.
    20. Thermann, R. and M.W. Hentze, Drosophila miR2 induces pseudo-polysomes and inhibits translation initiation. Nature, 2007. 447(7146): p. 875-8.
    21. Petersen, C.P., et al., Short RNAs repress translation after initiation in mammalian cells. Mol Cell, 2006. 21(4): p. 533-42.
    22. Iwasaki, S., T. Kawamata, and Y. Tomari, Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression. Mol Cell, 2009. 34(1): p. 58-67.
    23. Aravin, A.A., G.J. Hannon, and J. Brennecke, The Piwi-piRNA pathway provides an adaptive defense in the transposon arms race. Science, 2007. 318(5851): p. 761-4.
    24. Klattenhoff, C. and W. Theurkauf, Biogenesis and germline functions of piRNAs. Development, 2008. 135(1): p. 3-9.
    25. Lee, H.C., et al., qiRNA is a new type of small interfering RNA induced by DNA damage. Nature, 2009. 459(7244): p. 274-7.
    26. Hock, J. and G. Meister, The Argonaute protein family. Genome Biol, 2008. 9(2): p. 210.
    27. Farazi, T.A., S.A. Juranek, and T. Tuschl, The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members. Development, 2008. 135(7): p. 1201-14.
    28. Nolan, T., et al., The RNA-dependent RNA polymerase essential for post-transcriptional gene silencing in Neurospora crassa interacts with replication protein A. Nucleic Acids Res, 2008. 36(2): p. 532-8.
    29. Pak, J. and A. Fire, Distinct populations of primary and secondary effectors during RNAi in C. elegans. Science, 2007. 315(5809): p. 241-4.
    30. Warnecke, T., N.N. Batada, and L.D. Hurst, The impact of the nucleosome code on protein-coding sequence evolution in yeast. PLoS Genet, 2008. 4(11): p. e1000250.
    31. Fingerman, I.M., H.N. Du, and S.D. Briggs, Controlling histone methylation via trans-histone pathways. Epigenetics, 2008. 3(5): p. 237-42.
    32. Lewis, A. and W. Reik, How imprinting centres work. Cytogenet Genome Res, 2006. 113(1-4): p. 81-9.
    33. Reik, W., Stability and flexibility of epigenetic gene regulation in mammalian development. Nature, 2007. 447(7143): p. 425-32.
    34. Fowden, A.L., et al., Imprinted genes, placental development and fetal growth. Horm Res, 2006. 65 Suppl 3: p. 50-8.
    35. Ringrose, L. and R. Paro, Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet, 2004. 38: p. 413-43.
    36. Lyko, F., et al., Epigenetic regulation in Drosophila. Curr Top Microbiol Immunol, 2006. 310: p. 23-44.
    37. Ringrose, L. and R. Paro, Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development, 2007. 134(2): p. 223-32.
    38. Debeauchamp, J.L., et al., Chp1-Tas3 interaction is required to recruit RITS to fission yeast centromeres and for maintenance of centromeric heterochromatin. Mol Cell Biol, 2008. 28(7): p. 2154-66.
    39. Buhler, M., A. Verdel, and D. Moazed, Tethering RITS to a nascent transcript initiates RNAi- and heterochromatin-dependent gene silencing. Cell, 2006. 125(5): p. 873-86.
    40. Verdel, A., et al., RNAi-mediated Targeting of Heterochromatin by the RITS Complex. Science, 2004. 28(3): p. 127-32.
    41. Li, H., et al., An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing. Mol Cell, 2009. 34(2): p. 155-67.
    42. Shibuya, K., S. Fukushima, and H. Takatsuji, RNA-directed DNA methylation induces transcriptional activation in plants. Proc Natl Acad Sci U S A, 2009. 106(5): p. 1660-5.
    43. Mattick, J.S., et al., RNA regulation of epigenetic processes. Bioessays, 2009. 31(1): p. 51-9.
    44. Mathieu, O. and J. Bender, RNA-directed DNA methylation. J Cell Sci, 2004. 117(Pt 21): p. 4881-8.
    45. Wassenegger, M., RNA-directed DNA methylation. Plant Mol Biol, 2000. 43(2-3): p. 203-20.
    46. Wassenegger, M., Gene silencing. Int Rev Cytol, 2002. 219: p. 61-113.
    47. Wassenegger, M., The role of the RNAi machinery in heterochromatin formation. Cell, 2005. 122(1): p. 13-6.
    48. Bernstein, E., A.M. Denli, and G.J. Hannon, The rest is silence. Rna, 2001. 7(11): p. 1509-21.
    49. Tijsterman, M. and R.H. Plasterk, Dicers at RISC; the mechanism of RNAi. Cell, 2004. 117(1): p. 1-3.
    50. Agrawal, N., et al., RNA interference: biology, mechanism, and applications. Microbiol Mol Biol Rev, 2003. 67(4): p. 657-85.
    51. Filipowicz, W., RNAi: the nuts and bolts of the RISC machine. Cell, 2005. 122(1): p. 17-20.



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