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Qualität des Beitrags: Beteiligte Poster: zarathustra - kafri Forum: food4thought Forenbeschreibung: Ernährung einmal anders aus dem Unterforum: Hauptforum Antworten: 2 Forum gestartet am: Mittwoch 20.06.2007 Sprache: deutsch Link zum Originaltopic: Demodex-Milben Letzte Antwort: vor 16 Jahren, 8 Monaten, 30 Tagen, 14 Stunden, 43 Minuten
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Re: Demodex-Milben
zarathustra - 16.07.2007, 22:23Demodex-Milben
Ich habe das Thema schon mal kurz im Parasitenthread angesprochen, denke aber, dass es sich lohnen würde, in einem eigenen Thread darüber zu diskutieren.
Demodex-Milben spielen möglicherweise eine Rolle in der Enstehung von Akne als auch Haarausfall.
Hier mal ein empfehlenswerter Link zum Thema:
http://pestalert.ifas.ufl.edu/acne.htm
Es ist mir schon klar, dass diese Milbe nicht die erste und schon gar nicht die einzige Ursache dieser beiden Erkrankungen sein kann, dennoch halte ich es für möglich, dass diese Milben beide Probleme verstärken und zwar aus folgenden Gründen.
Demodex-Milben finden sich bei Patienten mit Akne Rosacea häufiger als bei gesunden Kontrollpersonen. Das wurde in etlichen Studien gezeigt:
Zitat:
J Cutan Pathol. 1998 Nov;25(10):550-2.
Demodex mites in acne rosacea.
Roihu T, Kariniemi AL.
Department of Dermatology, Helsinki University Central Hospital, Finland.
The hair follicle mites Demodex folliculorum and Demodex brevis and their role in the pathogenesis of rosacea have been the subject of much debate in the past. We studied the prevalence of Demodex mites in facial skin biopsies obtained from 80 patients with rosacea, 40 with facial eczematous eruption and 40 with lupus erythematosus discoides. The mite prevalence in the rosacea group (51%) was significantly higher than in the rest of the study population (eczema 28% and lupus discoides 31%). Demodex mites were found on all facial sites. The most infested areas in the whole study group were the forehead (49%) and the cheeks (44%). Males were more frequently infested (59%) than females (30%). We did not find any significant difference in mite counts of infested follicles between rosacea and the control group. A lympho-histiocytic cell infiltration was seen around the infested hair follicles. Our results suggest that Demodex mites may play a role in the inflammatory reaction in acne rosacea.
PMID: 9870674 [PubMed - indexed for MEDLINE]
Zitat:
J Am Acad Dermatol. 1993 Mar;28(3):443-8.Links
Comment in:
J Am Acad Dermatol. 1994 May;30(5 Pt 1):812-3.
The Demodex mite population in rosacea.
Bonnar E, Eustace P, Powell FC.
University Department of Ophthalmology, Mater Misercordiae Hospital, Dublin, Ireland.
BACKGROUND: The cause of rosacea is unknown; among other factors a causative role has been postulated for the hair follicle mites Demodex folliculorum and Demodex brevis. OBJECTIVE: Our purpose was to compare the population density of Demodex mites in facial skin of defined categories of patients with rosacea with control subjects. We also assessed the impact of tetracycline therapy on the mite population. METHODS: The population density and distribution of Demodex mites were studied in the facial skin of 42 patients with rosacea and 42 age- and sex-matched control subjects. Mites were counted in measured skin surface biopsy specimens obtained from six standard facial sites with cyanoacrylate glue. RESULTS: The mean mite count was 49.8 (range 2 to 158) in patients with rosacea and 10.8 (range up to 97) in control subjects (p < 0.001); the highest density of mites was found on the cheeks. A statistically significant increase in mites was found in all subgroups of rosacea, being most marked in those with steroid-induced rosacea. Mite counts in patients with rosacea before and after a 1-month course of oral tetracycline showed no significant difference. CONCLUSION: Increased mites may play a part in the pathogenesis of rosacea by provoking inflammatory or allergic reactions, by mechanical blockage of follicles, or by acting as vectors for microorganisms.
PMID: 8445060 [PubMed - indexed for MEDLINE]
Zitat:
J Eur Acad Dermatol Venereol. 2001 Sep;15(5):441-4.
Comment in:
J Eur Acad Dermatol Venereol. 2001 Sep;15(5):385.
Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea.
Georgala S, Katoulis AC, Kylafis GD, Koumantaki-Mathioudaki E, Georgala C, Aroni K.
National University of Athens, Department of Dermatology and Venereology, A. Sygros' Hospital, Greece.
BACKGROUND: Rosacea is a common chronic dermatosis that evolves in stages. The mite Demodex folliculorum has been implicated in its obscure aetiopathogenesis. AIM: To evaluate the importance of D. folliculorum in the aetiology and course of rosacea. METHODS: We studied 92 consecutive cases of papulopustular rosacea and 92 age- and sex-matched controls. Prevalence and density of D. folliculorum were estimated by microscopic examination of the expressed follicular content. Histological examination and immunohistochemical study of the inflammatory infiltrate were performed in 10 subjects (five with positive D. folliculorum finding and five with negative finding). RESULTS: D. folliculorum was detected in 83 (90.2%) of the 92 rosacea subjects but only 11(11.9%) of the controls. The mean mite density was 2.03 mites/visual field in the rosacea group (range 0-5, SD = 1.2) and 0.16 mites/visual field (range 0-2, SD = 0.52) in the control group. The difference was statistically significant (P < 0.0001) for both mite prevalence and density. Hair follicle infestation was associated with intense perifollicular infiltrate of predominantly (90-95%) CD4 helper/inducer T cells. We observed an increased number of macrophages and Langerhans cells only in those subjects with a positive D. folliculorum finding. CONCLUSIONS: Although Demodex mites do not seem to be the cause of rosacea, they may represent an important cofactor, especially in papulopustular rosacea. Immunohistochemical findings suggest that a delayed hypersensitivity reaction, possibly triggered by antigens of follicular origin, probably related to D. folliculorum, may occur, stimulating progression of the affection to the papulopustular stage.
PMID: 11763386 [PubMed - indexed for MEDLINE]
Zitat:
Int J Dermatol. 1998 Jun;37(6):421-5.
The significance of Demodex folliculorum density in rosacea.
Erbağci Z, Ozgöztaşi O.
Department of Dermatology, Faculty of Medicine, Gaziantep University, Turkey.
BACKGROUND: Demodex folliculorum has been reported in rosacea in a number of clinical studies. As the Demodex mite is also present in many healthy individuals, it has been suggested that the mite may have a pathogenic role only when it is present in high densities. Moreover, some authors have proposed that a mite density above 5/cm2 may be a criterion for the diagnosis of inflammatory rosacea. In this study, the possible role of D. folliculorum and the importance of mite density in rosacea were investigated using a skin surface biopsy technique. METHODS: Thirty-eight patients with rosacea and 38 age-and-sex-matched healthy subjects entered the study. With the skin surface biopsy technique, we obtained samples from three facial sites. We then determined the mite positivities, the mean mite counts in both study groups, the mean mite densities at each facial site and in the rosacea subgroups, and the mite densities above 5/cm2. RESULTS: The mean mite count in the rosacea group (6,684) was significantly higher than that in controls (2,868; p < 0.05). The cheek was the most frequently and heavily infested facial region. Ten rosacea patients and five normal subjects had mite densities over 5/cm2; the difference was not statistically significant (p > 0.05). CONCLUSIONS: Rosacea is a disease of multifactorial origin, and individual properties may modify the severity of the inflammatory response to Demodex. We suggest that a certain mite density is not an appropriate criterion in the diagnosis of the disease; nevertheless, large numbers of D. folliculorum may have an important role in the pathogenesis of rosacea, together with other triggering factors.
PMID: 9646125 [PubMed - indexed for MEDLINE]
Demodex-Milben finden sich auch häufiger bei Männern mit Haarausfall:
Zitat:
Androgenetic alopecia: the role of inflammation and Demodex (International Journal of Dermatology 2001, 40, 472-484)
The focus on androgenetic alopecia has been increasing in the last decade because of the availability of new, scientifically valid therapies such as Rogaine (Minoxidil) and Propecia (Finasteride). Hamilton showed in 1951, that 50% of men, and 40% of women demonstrated androgenetic alopecia by age 50.1 In 1993, 40% of men, and 30% of women showed androgenetic alopecia by age 40.2 This may re-ect the increased awareness of the problem, or interestingly might suggest that the real incidence is increasing. As our understanding evolves, the common mechanisms, including hormones, receptors, diet and supplements such as iron and B-12, all seem to play interesting and not totally understood roles. It is quite clear that manipulation of the enzyme 5 alpha reductase has a beneficial effect on this process, resulting in the great success thus far of Propecia. Inflammation is now becoming a focus of study in the problem of alopecia, and may represent a unique opportunity for additional therapeutic approaches. We have begun some studies that suggest the role of Demodex in the process of androgenetic alopecia, and perhaps indirectly in the inflammatory response in the scalp. The Nioxin Research Center Laboratories in Atlanta conducted the initial study on 54 subjects, and showed that 53 of 54 showed increased Demodex in their alopecic scalps, either before or after cosmetic peeling. We became interested in this, and conducted our own study of 99 patients, sponsored by Nioxin Labs. In this group of healthy young adults, we saw 40 caucasian patients positive for Demodex and 32 negative. Nine African-American subjects were positive and nine were negative. All five Hispanics were positive for Demodex, while all four Asian subjects were negative. In patients with thinning hair, 87.3 tested positive for Demodex, and 12% tested negative. In subjects with normal hair, the ratio was reversed; 13.6% with Demodex present and 86.4% tested negative for Demodex. The correlation of the presence of Demodex with thinning or early alopecia at the Nioxin Research Center was higher, at 98%. Our correlation with thinning was slightly lower, at 84%. The studies done here are minimally invasive studies, using the Nioscope, which provides magnification and visualization of the follicles, and, simply put, is a ‘follicular endoscope.’ This technique allows easy and rapid evaluation of the presence or absence of Demodex in a noninvasive technique. Vollmer also has reported the association of Demodex, inflammation and alopecia, lending support to our hypothesis that Demodex has been long considered as a major contributor to such diseases as seborrhea, rosacea and some ophthalmologic diseases. The inflammatory reactions associated with significant Demodex infestation have been considered by some as directly related and by others as coincidental. Progressive inflammation can progress to alopecia sometimes with and sometimes without scarring. This association, if real, simply may be related to the scarring, secondary to the inflammation induced by Demodex. The role of the inflammatory process in altering hormone metabolism is also an intriguing one that is of increasing fascination to investigators in the field of hair growth. Hormone metabolism locally is significant as the results of finasteride therapy attests. We find these initial results intriguing, suggesting that Demodex is a factor, not an epiphenomenon, and intend to follow up with these studies using sequential evaluations to determine if manipulation of the Demodex population would alter the process of progressive androgenetic alopecia. Further studies will be forthcoming.
Larry E. Millikan, MD New Orleans, LA
Immungeschwächte Hunde sind manchmal so stark von Demodex-Milben befallen, dass sie ihre Haare verlieren. Siehe z.B. diesen Link:
http://www.baltic-bulls.de/demodikose_beim_hund.htm
Ich finde es deshalb naheliegend, dass die Demodex-Milbe auch beim Menschen den Haarfollikel entzünden und den Haarausfall forden kann. Wenn die Domedexmilbe bei Haarausfall und Akne Rosacea gehäuft vorkommt, muss das natürlich noch nicht heissen, dass die Demodexmilbe diese Probleme auch verursacht. Es wäre ja möglich, dass eine Haut, die zu Haarausfall und Akne Rosacea neigt, einfach die besseren Überlebensbedingungen für diese Milbe schafft. Im obersten Link, heisst es u.a. dass diese Milben direkt von den Hormonen ihres Wirtes gesteuert werden. Das würde erklären, warum z.B. eine Hemmung der 5ar auch die Milben beeinflussen könnte und warum die Milben bevorzugt bestimmte Stellen des Haarbodens und des Kopfes befallen.
Was für mich für eine Beteiligung von Demodex-Milben spricht, ist die Tatsache, dass verschiedene Substanzen, die für Demodex-Milben tötlich sind, auch eine Wirkung gegen Akne und Haarausfall gezeigt haben. Das Antischuppenschampoo Nizoral, dem auch eine Wirkung gegen Alopezie nachgesagt wird, enthält den Wirkstoff Ketogonazol. Dieser Wirkstoff ist chemisch eng verwandt mit dem Wirkstoff Metronidazole, von dem eine Wirkung gegen Demodex nachgewiesen ist. Auch verschiedene natürliche Substanzen haben eine Wirkung gegen Demodex gezeigt, so z.B. Sanddorn und Teebaumöl.
Auf einem amerikanischen Haarausfallforum hat jemand berichtet, seinen Haarausfall durch die regelmässige Behandlung mit Sanddornseife und -öl komplett unter Kontrolle gebracht zu haben und sogar Neuwachstum erreicht zu haben;
http://www.regrowth.com/hairloss%2Dforums/viewthread.cfm?f=5&t=17015
Re: Demodex-Milben
kafri - 18.07.2007, 21:42
Die Milbentheorie finde ich interessant, wenn ich auch generell von Parasitenkuren etc. wenig halte. Stell dir vor, als ich vor ca. 9 Jahren zum ersten Mal bei ner Hautärztin war, versicherte mir diese dass ich keine Akne sondern Milben hätte. Sie meinte u.a. das daran zu erkennen, dass sich die Entzündungen und Pickel bei mir im Gesicht in Linien formiert haben. Dies wären die Fressgänge der Milben, meinte sie. Ich habe daraufhin eine Bachblütenlotion bekommen und ein äußerliches Antibiotika. Hat auch sehr gut geholfen, bis ich es abgesetzt habe...
Ich denke auch heute noch ab und an über diese Milbentheorie nach. Es könnte schon durchaus sein, dass da was dran ist. Was kann man dagegen tun, wenn "Le terrain est tout, le germe n'est rien"?
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